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James Versalovic Lab

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  7. Immunomodulins Identified in Lactobacillus reuteri

Immunomodulins Identified in Lactobacillus reuteri

Master
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Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling.
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Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling.

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Histamine produced by L. reuteri is not modified
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Histamine produced by L. reuteri is not modified

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Histamine Concentration Correlates with TNF Inhibitory Activity. Histamine quantified using Triple Quadrupole MS
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Histamine Concentration Correlates with TNF Inhibitory Activity. Histamine quantified using Triple Quadrupole MS

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Histamine Produced by L. reuteri Inhibits the ERK Signaling Pathway
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Histamine Produced by L. reuteri Inhibits the ERK Signaling Pathway

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Histamine Produced by L. reuteri Inhibits TNF via the H2 Receptor
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Histamine Produced by L. reuteri Inhibits TNF via the H2 Receptor

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Histamine Produced by L. reuteri Inhibits TNF by Interacting with the H2 Receptor and inhibiting ERK Signaling
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Histamine Produced by L. reuteri Inhibits TNF by Interacting with the H2 Receptor and inhibiting ERK Signaling

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Publication:

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Thomas CM, Hong T, van Pijkeren JP, Hemarajata P, Trinh DV, Hu W, Britton RA, Kalkum M, Versalovic J. . PLoS One. 2012;7(2):e31951. Epub 2012 Feb 22. PubMed PMID: 22384111; PubMed Central PMCID: PMC3285189. Article