7mÊÓƵ

Email

psaha@bcm.edu

Positions

Associate Professor/ Co-Director Mouse Metabolism & Phenotyping Core

Mol & Cell Biology
7mÊÓƵ
Houston, TX US

Co- Director

Mouse Metabolism & Phenotyping core
Advanced Technology Core
Baylor college of Medicine

Director

Mouse Metabolism Core
Diabetes Research Center
Baylor college of Medicine

Associate Professor

Medicine
Endocrinology
Baylor college of Medicine

Education

Advanced Training from Baylor College Of Medicine

01/2001 - Houston, TX United States

Advanced Training from National Institute Of Cholera And Enteric Diseases

01/1998 - Calcutta, India

Ph.D. from Calcutta University

01/1996 - India, India

M.Sc. from Calcutta University

01/1990 - India, India

B.Sc. from Calcutta University

01/1987 - India, India

Professional Interests

• Diabetes & Obesity related Research

Professional Statement

The use of mouse models is a key research strategy for investigation of all kind of human diseases included but not limited to metabolic disorders, cancer, aging neurological disorders, etc. In depth characterization of mouse models requires careful, specialized techniques and procedures, most requiring unique instrumentation and expertise. But to get phenotypic and metabolic date on experimental model is time consuming, expensive and always lack of expertise in doing as well as explaining the outcome. Only solution of this problem is to have a shared resource and can mobilize more researchers and help them to explore their findings by the expert in the field. From here I got the idea to develop a core service to support the entire research community within 7mÊÓƵ and beyond. I have a broad background in biochemistry, with specific trainings and expertise in key research areas for this type of shared platform. Since 1992, I’m actively engaged in basic research out of which I spent 12 years in the field of diabetic and metabolic disorder. I have a track record of success during more than twenty years of tenure in the bio medical research. Focused and highly motivated scientific research professional with strong scientific research experience in diabetes, inflammation, obesity, cardiovascular diseases and oncology. Major accomplishment of my research included but not limited to
• Rescue of Human Familial Hypercholesterolemia (Nature Communication).
• Starvation and Cellular Lipid Metabolism (Nature Cell).
Resume: Saha PK 10
• Inflammation, Bone Marrow-derived Proinsulin-producing cells and Insulin Resistance (FASEB).
• Steroid Receptor Coactivator 2 in metabolism and Von Gierke's disease (Science).
• Angiogenesis and Obesity Reversal ( Nature Medicine)
• Peptidomimetic Weight loss in Obese Monkeys (Sci Transl Med)
• Antidiabetic Effects of CDDO-Me, a Cancer Drug (JBC)
• Nuclear Receptor CAR and Liver Diseases (PNAS).
Based on above idea, finally I developed a core service (Mouse Metabolism Core) for the researcher and providing service to the investigator since 2008. Mouse metabolism core performed timely in vivo characterization of mouse models using state-of-the-art assays and measurements in a systematic and cost-effective manner. The MMC provides a combination of services that include static, dynamic, and continuous monitoring of metabolic parameters, coupled with individualized consultation and expert interpretation. For these reasons, the MMC is an essential and highly used core in BCM as well as in outside Institute including M.D. Anderson Cancer Center (MDACC), The Methodist Hospital Research Institute (TMHRI), UT Health Science Center (UTHSC), Dana-Farber Cancer Center (DFCC), MIT, City of hope :Beckman Research Institutes (COH), The hospital for sick children in Canada (SICKKIDS) and so on. The MMC interacts closely with the Metabolomics Core. Comprehensive metabolic phenotyping by the MMC and dissection of the underlying metabolic pathways by the metabolomics core will be powerful state-of-the-art investigative tools soon and will enhance research in cancer and metabolism and its related field.

Websites

Selected Publications

• Settembre C, De Cegli R, Mansueto G, Saha PK, Vetrini F, Visvikis O, Huynh T, Carissimo A, Palmer D, Jürgen Klisch T, Wollenberg AC, Di Bernardo D, Chan L, Irazoqui JE, Ballabio A "." Nat. Cell Biol.. 2013 Jun;15(6):647-58. Pubmed PMID:
• Kolonin MG, Saha PK, Chan L, Pasqualini R, Arap W "." Nat. Med.. 2004 Jun;10(6):625-32. Pubmed PMID:
• Duerrschmid C, He Y, Wang C, Li C, Bournat JC, Romere C, Saha PK, Lee ME, Phillips KJ, Jain M, Jia P, Zhao Z, Farias M, Wu Q, Milewicz DM, Sutton VR, Resume: Saha PK 8 Moore DD, Butte NF, Krashes MJ, Xu Y and Chopra AR "." Nat Med. 2017; Pubmed PMID:
• Romere C, Duerrschmid C, Bournat J, Constable P, Jain M, Xia F, Saha P, Solar MD, Dean A, York B, Sarkar P, Rendon D, Gaber W, LeMaire SA, Coselli JS, Ramirez F, Milewicz DM, Sutton VR, Butte NF, Moore DD and Chopra AR "." Cell. 2016; Pubmed PMID: