Michael Bround
Picture
Michael Bround
Assistant Professor
Positions
- Assistant Professor
-
Integrative Physiology
7m视频
Houston, TX US
Addresses
- BCM-Anderson Hall (Office)
-
One Baylor Plaza
Room 413BB
Houston, TX 77030
United States
- BCM-Anderson Hall (Lab)
-
One Baylor Plaza
Room 413B
Houston, TX 77030
United States
Education
- BSc from University of British Columbia
- Vancouver, Canada
- Biochemistry
- PhD from University of British Columbia
- Vancouver, Canada
- Cell Biology
- Postdoctoral Fellowship at Cincinnati Children's Hospital
- Cincinnati, United States
- Molecular Cardiovascular Biology
Professional Interests
- Mitochondria
- Cellular Metabolism
- Cell Death
- Calcium Signaling
- Molecular Mechanisms of Disease
Professional Statement
As a scientist I鈥檓 interested in how molecular biology controls cell function and effects whole body physiology in health and disease. My research focuses on the mitochondria, an important cellular organelle that is the site of high energy biochemistry in cells. Mitochondria are responsible for generating the majority of cellular ATP, the energy currency of the cell, as well as producing the reducing potential and molecular building blocks that underpin biosynthesis. Specifically, I鈥檓 interested in how this important organelle communicates with the cell to regulate metabolic function. Under homeostatic conditions the cell and mitochondria synchronize to couple energy production with demand, however in several diseases, such as diabetes and heart failure, this communication breaks down and energy metabolism becomes dysfunctional. In some illnesses, such as cardiac infarction, muscular dystrophy, and neurodegenerative disease, aberrant mitochondrial signals activate cell death processes which cause tissue necrosis. My goal is to understand the molecular biology of mitochondrial signaling to maximize energy metabolism and mitochondrial quality control, while preventing pathogenic cell death processes. The hope is this research will lead to new treatments for diseases such as cardiac ischemia reperfusion injury, muscular dystrophy, and Alzheimer鈥檚 disease.Selected Publications
- Michael J Bround, Julian R Havens, Allen J York, Michelle A Sargent, Jason Karch, Jeffery D Molkentin "." Science Advances. 2023 Aug 25;9(34):eadi2767. Pubmed PMID:
- Michael J Bround, Eaman Abay, Jiuzhou Huo, Julian R Havens, Allen J York, Donald M Bers, Jeffery D Molkentin "." Scientific Reports. 2024 Mar 21;14(1):6751. Pubmed PMID:
- Jason Karch*, Michael J Bround*, Hadi Khalil, Michelle A Sargent, Nadina Latchman, Naohiro Terada, Pablo M Peixoto, Jeffery D Molkentin "." Science Advances. 2019 Aug 28;5(8):eaaw4597. Pubmed PMID:
- Michael J Bround, Donald M Bers, Jeffery D Molkentin "." JMCC. 2020 May 23;Jul(144):A1-A13. Pubmed PMID:
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