Aaron Cox, Ph.D.
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Aaron Cox, Ph.D.
Assistant Professor
Positions
- Assistant Professor
-
Medicine
Endocrinology, Diabetes, and Metabolism
7m视频
Houston, TX US
Addresses
- BCM-Alkek Building for Biomedical Research (Lab)
-
One Baylor Plaza
Houston, TX 77030
United States
Education
- Postdoctoral Fellowship at 7m视频
- 01/2019 - Houston
- Obesity, Metabolism, and Inflammation
- Postdoctoral Fellowship at 7m视频
- 02/2018 - Houston
- Beta Cell Biology
- PhD from University of Western Ontario
- 06/2011 - London, ON Canada
- Physiology
- BSc from University of Western Ontario
- 06/2004 - London, ON Canada
- Physiology
Professional Interests
- Islet Biology
- Type 1 & 2 Diabetes
- Obesity & Insulin Resistance
- Immune Cell Metabolism
Professional Statement
Diabetes is marked by a relative or absolute deficiency of insulin-producing beta cells. Strategies to expand beta cell mass have significant potential to restore glucose control in diabetes patients. Beta cells demonstrate tremendous capacity to proliferate during obesity, although the mechanisms are unclear. We are focused on uncovering the hormonal and metabolic signals that drive beta cell expansion in obesity. In particular, we are examining the central and islet specific mechanisms by which leptin regulates beta cells proliferation. Our goal is to identify novel targets for the expansion of endogenous beta cells in patients with diabetes. We are employing new genetic mouse models, metabolic phenotyping, and molecular approaches to examine the effects of obesity-derived signals on beta cells.Websites
Selected Publications
- Cox AR, Masschelin PM, Saha PK, Felix JB, Sharp R, Lian Z, Xia Y, Chernis N, Bader DA, Kim KH, Li X, Yoshino J, Li X, Sun Z, Wu H, Coarfa C, Moore DD, Klein S, Sun K, Hartig SM "." Cell Metabolism. 2022 Dec;34(12):1932-1946. Pubmed PMID:
- Hartig SM, Cox AR "." Journal of Molecular Medicine. 2020 Apr;98(4):451-467. Pubmed PMID:
- Cox AR, Chernis N, Masschelin PM, Hartig SM "." Endocrinology. 2019 Jul;160(7):1645-58. Pubmed PMID:
- Cox AR, Lam CJ, Rankin MM, Rios JS, Chavez J, Bonnyman CW, King KB, Wells RA, Anthony D, Tu JX, Kim JJ, Li C, Kushner JA "." Endocrinology. 2017 Jun;158(6):1701-14. Pubmed PMID:
- Cox AR, Lam CJ, Rankin MM, King KA, Chen P, Martinez R, Li C, Kushner JA "." Diabetologia. 2016 Jun;59(6):1231-41. Pubmed PMID:
- Cox AR, Barrandon O, Cai EP, Rios JS, Chavez J, Bonnyman CW, Lam CJ, Yi P, Melton DA, Kushner JA "." Plos One. 2016 Jul; Pubmed PMID:
- Masschelin PM, Cox AR, Chernis N, Hartig SM "." Frontiers in Physiology. 2020 Jan;10:1638. Pubmed PMID:
- Chernis N, Masschelin P, Cox AR, Hartig SM "." Am J Physiol Cell Physiol. 2020 Jan;318(1):C63-C72. Pubmed PMID:
- Zhang L, Sosinowski T, Cox AR, Cepeda JR, Sekhar NS, Hartig SM, Miao D, Yu L, Pietropaolo M, Davidson HW. "." J Autoimmun. 2019 Jan;96:50-58. Pubmed PMID:
- Vonberg AD, Acevedo-Calado M, Cox AR, Pietropaolo SL, Gianani R, Lundy SK, Pietropaolo M "." JCI Insight. 2018 Dec 6;3(23) Pubmed PMID:
- Cox AR, Kushner JA. "." Diabetes. 2017 Nov;66(11):2738-2740. Pubmed PMID:
- Lam CJ, Chatterjee A, Shen E, Cox AR, Kushner JA "." Diabetes. 2018 Dec 14; Pubmed PMID:
- Lam CJ, Cox AR, Jacobson DR, Rankin MM, Kushner JA "." Diabetes. 2018 Apr;67(4):674-686. Pubmed PMID:
- Lam CJ, Jacobson DR, Rankin MM, Cox AR, Kushner JA "." J Clin Endocrinol Metab. 2017 Aug;102(8):2647-59. Pubmed PMID:
- Cox AR, Lam CJ, Bonnyman CW, Chavez J, Rios JS, Kushner JA "." Diabetologia. 2015 Jul;58(7):1523-31. Pubmed PMID:
- Shields EJ, Lam CJ, Cox AR, Rankin MM, Van Winkle TJ, Hess RS, Kushner JA "." Plos One. 2015 Jun;10(6) Pubmed PMID:
- Cox AR, Beamish CA, Carter DE, Arany EJ, Hill DJ "." Exp Biol Med (Maywood). 2013 Oct;238(10):1147-59. Pubmed PMID:
- Cox AR, Gottheil SK, Arany EJ, Hill DJ: "." Pediatr Res. 2010 Jul;68(1):16-22. Pubmed PMID:
- He Y, Brouwers B...Cox AR, ...Hartig SM, Liao L, Xu J, Barroso I, Mokrosinski J, Elmquist JK, Xu Y, Farooqi IS "." Nat Med. 2022 Dec;28(12):2537-2546. Pubmed PMID:
Funding
- Leptin regulation of beta cell proliferation - #1R56DK128098 (07/18/2022 - 06/30/2023) Grant funding from NIH NIDDK
- The goal of this award is to generate preliminary data to support observations that leptin regulates pancreatic islet delta cell function.
- Novel Leptin-Islet Signaling Pathway Regulates Beta Cell Function and Proliferation - #PR220954 (01/02/2023 - 12/31/2024) Grant funding from DoD PRMRP Discovery Award
- The goal of this project is to understand how leptin regulates islet function and beta cell proliferation.
- GABP is a novel regulator of beta cell metabolism and proliferation - #R03DK135458 (05/01/2023 - 04/30/2025) NIH NIDDK
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