Research on infectious diseases within emergency medicine plays a crucial role in understanding and effectively managing the spread and impact of infectious agents in acute care settings. This research focuses on various aspects, including surveillance and early detection of emerging pathogens, evaluating diagnostic techniques, studying the efficacy of antimicrobial treatments, and developing strategies to prevent healthcare-associated infections. By investigating the epidemiology, transmission dynamics, and clinical manifestations of infectious diseases in emergency departments, researchers aim to enhance the diagnosis, treatment, and prevention of these conditions, ultimately improving patient outcomes and public health preparedness.
Our research chief, , is dual-boarded in PEM and ID, and is the current chair of the Pediatric Emergency Medicine Collaborative Research Committee ( where she led a 23-center study of neonatal herpes simplex virus and has been the site PI on other multicenter studies on hemolytic uremic syndrome, fusobacterial infections, omphalitis, and mastitis. She is a consultant to the Centers for Disease Control and Prevention and the World Health Organization (WHO) for childhood tuberculosis. She participated in the updated Surviving Sepsis pediatric guidelines.
Shubhada Hooli has worked extensively on the prevention of morbidity and mortality for young children with pneumonia in low- and middle-income countries (LMICs). She has served as a WHO consultant for childhood pneumonia and is a member of the WHO's Research Partnership to Assess WHO Recommendations () and the Pediatric Acute Lung Injury and Sepsis Investigators Global Health () network. Nina Singh, a recipient of the , is the PECARN site PI for a study evaluating fluid resuscitation for children STEC organisms to prevent progression to hemolytic uremic syndrome. She was also the PI of a prospective interventional study on treatment modalities for oral ulcers.
Faculty with a research focus on infectious diseases:
- Gina Aloisio, M.D., MPH: organoids as models for respiratory tract infections
- Email: Gina.Aloisio@bcm.edu
- Andrea Cruz, M.D., MPH: prediction rules for infectious diseases, neonatal herpes simplex virus, sepsis, tuberculosis
- Email: acruz@bcm.edu
- Twitter: @atcruz97
- Shubhada Hooli, M.D., MPH: pneumonia in low- and middle-income countries
- Email: Shubhada.Hooli@bcm.edu
- Twitter: @ShubhadaH
- Binita Patel, M.D.: sepsis
- Email: bxpatel@texaschildrens.org
- Nina Singh, M.D.: hemolytic uremic syndrome, stomatitis
- Email: Nidhi.Singh@bcm.edu
- Twitter: @NinaVSingh
Chokkalla AK, Tam E, Liang R, Cruz AT, Devaraj S. . Clin Chim Acta. 2023. PMID 37201742.
Lubell TR, Cruz AT, Tanverdi MS, Ochs JB, Lobritto S, Saini S, Mavrogiorgos E, Dayan PS. . Pediatr Infect Dis J. 2023. PMID 37171971.
Cruz AT, Seddon JA. Pediatrics. 2023. PMID 36950927.
Chiang SS, Waterous PM, Atieno VF, Bernays S, Bondarenko Y, Cruz AT, et al. . J Adolesc Health. 2023. PMID 36803849.
Hooli S, King C, McCollum ED, Colubourn T, Lufesi N, Mwansambo C, Gregory CJ, Thamthitiwat S, Cutland C, Madhi SA, Nunes MC, Gessner BD, Hazir T, Mathew JL, Addo-Yobo E, Chisaka N, Hassan M, Hibberd PL, Jeena P, Lozano JM, MacLeod WB, Patel A, Thea DM, Nguyen NTV, Zaman SM, Ruvinsky RO, Lucero M, Kartasasmita CB, Turner C, Asghar R, Banajej S, Iqbal I, Maluen-Radovan I, Mino-Leon G, Saha SK, Santosham M, Singhi S, Awasthi S, Bavdekar A, Chou M, Nymadawa P, Pape JW, Paranhos-Baccala G, Picot VS, Rakoto-Andrianarivelo M, Rouzier V, Russomando G, Sylla M, Vanhems P, Wang J, Basnet S, Strand TA, Neuman MI, Arroyo LM, Echavarria M, Bhatnagar S, Wadhwa N, Lodha R, Aneja S, Gentile A, Chadha M, Hirve S, O'Grady KF, Clara AW, Rees CA, Campbell H, Nair H, Falconer J, Williams LJ, Horne M, Qazi SA, Nisar YB; Pneumonia REsearch Partnership to Assess WHO REcommendations (PREPARE) study group. . Int J Infect Dis. 2023. PMID 36805325.
Martin H, Falconer J, Addo-Yobo E, Aneja S, Arroyo LM, Asghar R, Awasthi S, Banajeh S, Bari A, Basnet S, Bavdekar A, Bhandari N, Bhatnagar S, Bhutta ZA, Brooks A, Chadha M, Chisaka N, Chou M, Clara AW, Colbourn T, Cutland C, D'Acremont V, Echavarria M, Gentile A, Gessner B, Gregory CJ, Hazir T, Hibberd PL, Hirve S, Hooli S, Iqbal I, Jeena P, Kartasasmita CB, King C, Libster R, Lodha R, Lozano JM, Lucero M, Lufesi N, MacLeod WB, Madhi SA, Mathew JL, Maulen-Radovan I, McCollum ED, Mino G, Mwansambo C, Neuman MI, Nguyen NTV, Nunes MC, Nymadawa P, O'Grady KF, Pape JW, Paranhos-Baccala G, Patel A, Picot VS, Rakoto-Andrianarivelo M, Rasmussen Z, Rouzier V, Russomando G, Ruvinsky RO, Sadruddin S, Saha SK, Santosham M, Singhi S, Soofi S, Strand TA, Sylla M, Thamthitiwat S, Thea DM, Turner C, Vanhems P, Wadhwa N, Wang J, Zaman SM, Campbell H, Nair H, Qazi SA, Nisar YB; World Health Organization Pneumonia Research Partnership to Assess WHO Recommendation (PREPARE) study group. . J Glob Health. 2022. PMID 36579417.
McGonagle EA, Caravite DJ, Grundmeier RW, Schmidt SK, May LS, Cohen DM, Cruz AT, Tu SP, Bajaj L, Dayan PS, Mistry RD. . Appl Clin Inform. 2023. PMID 36754066.
Florin TA, Melnikow J, Gosdin M, Ciuffetelli R, Benedetti J, Ballard D, Gausche-Hill M, Kronman MP, Martin LA, Mistry RD, Neuman MI, Palazzi DL, Patel SJ, Self WH, Shah SS, Shah SN, Sirota S, Cruz AT, Ruddy R, Gerber JS, Kuppermann N. . J Pediatr Infect Dis Soc. 2023. PMID 36625856.
Cruz AT, Starke JR. . J Adolsc Health. 2023. PMID 36567181.
Chernick LS, Bugaighis M, Britton L, Cruz AT, Goyal MK, Mistry RD, Reed JL, Bakken S, Santelli JS, Dayan PS. . Acad Emerg Med. 2022. 36478023.
Cruz AT, Tanverdi MS, Swartz SJ, Dayan PS, Combs VA, Lubell TR. . Pediatr Infect Dis J. 2022. PMID 36102710.
Cameron LH, Cruz AT. . Curr Opin Infect Dis. 2022. PMID 35947056.
Mahajan P, VanBuren JM, Tzimenatos L, Cruz AT, et al. . Pediatrics. 2022. PMID 36097858.
Pruitt CM, Nigrovic LE, Freedman SB, Bradin SA, Curtis SJ, Lyons TW, Miller AS, Okada PJ, Schmidt SM, Schnadower D, Thomson JE, Cruz AT. . Pediatr Infect Dis J. 2022. PMID 35797706.
Click ES, Song R, Smith JP, Mchembere W, Fajans M, Hariri P, Okeyo E, McCarthy KD, Gethi D, Odeny L, Musau S, Okumu A, Orwa J, Perez-Velez CM, Wright CA, Andres M, Marais BJ, Schaaf HS, Graham SM, Cruz AT, Cain KP. . Pediatr Infect Dis J. 2022. PMID 35703284.
Kaplan RL, Cruz AT, Freedman SB, Smith K, Freeman J, Lane RD, Michelson KA, Marble RD, Middelberg LK, Bergmann KR, McAneney C, Noorbakhsh, Pruitt C, Shah N, Badaki-Makun O, Schnadower D, Thompson AD, Blackstone MM, Abramo TJ, Srivastava G, Avva U, Samuels-Kalow M, Morientes O, Kannikeswaran N, Chaudhari PP, Strutt J, Vance C, Haines E, Khanna K, Gerard J, Bajaj L. . Pediatrics. 2022. PMID 35441224.
Cruz AT, Denison MR. . Pediatrics. 2022. PMID 35301523.
Swamy P, Duran C, Gupta A, Misra S, Fredricks K, Cruz AT. . J Public Health Manag Pract. 2022. PMID 35121709.
Rees CA, Colbourn T, Hooli S, et al. . BMJ Glob Health. 2022. PMID 35428680.
O'Bryant SC, Momin Z, Camp E, Jones J, Meskill S. . J Clin Virol. 2022. PMID 35101733.
Baumann BM, Rodriguez RM, DeLaroche AM, Rayburn D, Eucker SA, Nadeau NL, Drago LA, Cullen D, Meskill SD, Bialeck S, Gillman M. . Ann Emerg Med. 2022. PMID 35525709.
Depinet H, Macias CG, Balamuth F, Lane RD, Luria J, Melendez E, Myers SR, Patel B, Richardson T, Zaniletti I, Paul R; American Academy of Pediatrics Pediatric Septic Shock Collaborative (PSSC) Investigators. . Pediatrics. 2022. PMID 35229124.
Gardiner MA, Allen CH, Singh NV, Tresselt E, Young A, Hurley KK, Wilkinson MH. . Pediatr Emerg Care. 2022. PMID 34711757.
Souganidis ES, Patel B, Sampayo EM. . Pediatr Emerg Care. 2022. PMID 35696307.
Greenfield BW, Lowery BM, Starke HE, Mayorquin L, Stanford C, Camp EA, Cruz AT. . Am J Emerg Med. 2021. PMID 34879497.
Cruz AT, Nigrovic LE, Xie J, Mahajan P, Thomson JE, Okada PJ, Uspal NG, Mistry RD, Garro A, Schnadower D, Kulik DM, Curtis SJ, Miller AS, Fleming AH, Lyons TW, Balamuth F, Arms JL, Louie J, Aronson PL, Thompson AD, Ishimine PT, Schmidt SM, Pruitt CM, Shah SS, Grether-Jones KL, Bradin SA, Freedman SB. . Pediatrics. 2021. PMID 34446535.
Kaplan RL, Cruz AT, Michelson KA, McAneney C, Blackstone MM, Pruitt CM, Shah N, Noorbakhsh KA, Abramo TJ, Marble RD, Middelberg L, Smith K, Kannikeswaran N, Schnadower D, Srivastava G, Thompson AD, Lane RD, Freeman JF, Bergmann KR, Morientes O, Gerard J, Badaki-Makun O, Avva U, Chaudhari PP, Freedman SB, Samuels-Kalow M, Haines E, Strutt J, Khanna K, Vance C, Bajaj L. . Pediatrics. 2021. PMID 34187909.
Rees CA, Hooli S, King C, McCollum ED, Colbourn T, Lufesi N, Mwansambo C, Lazzerini M, Madhi SA, Cutland C, Nunes M, Gessner BD, Basnet S, Kartasasmita CB, Mathew JL, Zaman SMAU, Paranhos-Baccala G, Bhatnagar S, Wadhwa N, Lodha R, Aneja S, Santosham M, Picot VS, Sylla M, Awasthi S, Bavdekar A, Pape JW, Rouzier V, Chou M, Rakoto-Andrianarivelo M, Wang J, Nymadawa P, Vanhems P, Russomando G, Asghar R, Banajeh S, Iqbal I, MacLeod W, Maulen-Radovan I, Mino G, Saha S, Singhi S, Thea DM, Clara AW, Campbell H, Nair H, Falconer J, Williams LJ, Horne M, Strand T, Qazi SA, Nisar YB, Neuman MI; World Health Organization PREPARE study group48. . J Glob Health. 2021. 34737862.
Cruz AT, Zeichner SL. . Pediatrics. 2021. PMID 34158313.
Ikeda S, Cruz AT, Starke JR. . Int J Tuberc Lung Dis. 2021. PMID 34049610.
Starke JR, Cruz AT. . JAMA Pediatr. 2021. PMID 33616639.
Lin CY, Xie J, Freedman SB, McKee RS, Schnadower D, Tarr PI, Finkelstein Y, Desai NM, Lane RD, Bergmann KR, Kaplan RL, Hariharan S, Cruz AT, et al. . J Pediatr. 2021. PMID 33417918.
McLaren SH, Cruz AT, Yen K, et al. . Pediatrics. 2021. PMID 33288730.
Singh NV, Gabriele GA, Wilkinson MH. . Ann Emerg Med. 2021. PMID 33867179.
McCollum ED, King C, Ahmed S, Hanif AAM, Roy AD, Islam AA, Colbourn T, Schuh HB, Ginsburg AS, Hooli S, Chowdhury NH, Rizvi SJR, Begum N, Baqui AH, Checkley W. BMJ Open Respir Res. 2021. PMID 34728475.
Neubauer HC, Hall M, Lopez MA, Cruz AT, et al. . J Hosp Med. 2021. PMID 33617441.
Vo AT, Liu DR, Schmidt AR, Festekijan A. Am J Emerg Med. 2021. PMID: 33915447.
Starosolski Z, Admane P, Dunn J, Kaziny B, Huisman TAGM, Annapragada A. . AJNR Am J Neuroradiol. 2020. PMID: 32855191.
Colbourn T, King C, Beard J, Phiri T, Mdala M, Zadutsa B, Makwenda C, Costello A, Lufesi N, Mwansambo C, Nambiar B, Hooli S, French N, Bar Zeev N, Qazi SA, Bin Nisar Y, McCollum ED. . PLoS Med. 2020. PMID 33095763.
Cruz AT, Lane RD, Balamuth F, Aronson PL, Ashby DW, Neuman MI, Souganidis ES, Alpern ER, Schlapbach LJ. J Am Coll Emerg Physicians Open. 2020. PMID: 33145549.
Cruz AT, Shaman J, Dayan PS. Pediatrics. 2020. PMID: 32994181.
Zeichner SL, Cruz AT. Pediatrics. 2020.PMID: 32973121.
Chiang SS, Dolynska M, Rybak NR, Cruz AT, Aibana O, Sheremeta Y, Petrenko V, Mamotenko A, Terleieva I, Horsburgh CR Jr, Jenkins HE. ERJ Open Res. 2020. PMID: 32964003.
Alpern ER, Kuppermann N, Blumberg S, Roosevelt G, Cruz AT, Nigrovic LE, Browne LR, VanBuren JM, Ramilo O, Mahajan P; PEDIATRIC EMERGENCY CARE APPLIED RESEARCH NETWORK (PECARN). Hosp Pediatr. 2020. PMID: 32868377.
Lamb GS, Cruz AT, Camp EA, Javier M, Montour J, Piper T, Shah UA, Starke JR. Emerg Infect Dis. 2020. PMID: 32687465.
Cruz AT, Ellison AM, Johnson TJ. JAMA Pediatr. 2020. PMID: 32663241
Tsze DS, Cruz AT, Mistry RD, Gonzalez AE, Ochs JB, Richer L, Kuppermann N, Dayan PS. J Pediatr. 2020. PMID: 32446483.
Cruz AT, Schwartzman K, Kitai I. Int J Tuberc Lung Dis. 2020. PMID: 32317055.
Lyons TW, Garro AC, Cruz AT, Freedman SB, Okada PJ, Mahajan P, Balamuth F, Thompson AD, Kulik DM, Uspal NG, Arms JL, Nigrovic LE; HERPES SIMPLEX VIRUS STUDY GROUP OF THE PEDIATRIC EMERGENCY MEDICINE COLLABORATIVE RESEARCH COMMITTEE (PEM CRC). Pediatrics. 2020. PMID: 32205466.
Green RS, Cruz AT, Freedman SB, Fleming AH, Balamuth F, Pruitt CM, Lyons TW, Okada PJ, Thompson AD, Mistry RD, Aronson PL, Nigrovic LE; Herpes Simplex Virus Study Group of the Pediatric Emergency Medicine Collaborative Research Committee (PEM CRC). Acad Emerg Med. 2020. PMID: 32187765.
Cruz AT, Zeichner SL. Pediatrics. 2020. PMID: 32179659.
Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Pediatr Crit Care Med. 2020. PMID: 32032273.
Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Pediatr Crit Care Med. 2020. PMID: 32032264.
Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Intensive Care Med. 2020. PMID: 32030529.
Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Intensive Care Med. 2020. PMID: 32030528.
Snow KJ, Cruz AT, Seddon JA, Ferrand RA, Chiang SS, Hughes JA, Kampmann B, Graham SM, Dodd PJ, Houben RM, Denholm JT, Sawyer SM, Kranzer K. Lancet Child Adolesc Health. 2020. PMID: 31753806.
McKee RS, Schnadower D, Tarr PI, Xie J, Finkelstein Y, Desai N, Lane RD, Bergmann KR, Kaplan RL, Hariharan S, Cruz AT, Cohen DM, Dixon A, Ramgopal S, Rominger A, Powell EC, Kilgar J, Michelson KA, Beer D, Bitzan M, Pruitt CM, Yen K, Meckler GD, Plint AC, Bradin S, Abramo TJ, Gouin S, Kam AJ, Schuh A, Balamuth F, Hunley TE, Kanegaye JT, Jones NE, Avva U, Porter R, Fein DM, Louie JP, Freedman SB; Pediatric Emergency Medicine Collaborative Research Committee and Pediatric Emergency Research Canada. Clin Infect Dis. 2020. PMID: 31125419.
Chiang SS, Park S, White EI, Friedman JF, Cruz AT, Del Castillo H, Lecca L, Becerra MC, Seddon JA. J Pediatric Infect Dis Soc. 2020. PMID: 30715497.
Nolan MS, Cruz AT, Erickson T. J Pediatric Infect Dis Soc. 2020. PMID: 30624683.
Souganidis E, Abbadessa MK, Ku B, Minich C, Lavelle J, Zorc J, Balamuth F. Pediatr Emerg Care. 2020. PMID: 33003131.
Thomas VA, Crouse HL, Murray KO, Hsu DC, Camp EA, Cruz AT. . Pediatr Emerg Care. 2020. PMID 29538263.
