Recent publications (Reverse chronological order)
Doerfler A.M.*, Park S.H.*, Assini J.M., Youssef A., Saxena L., Yaseen A.B., De Giorgi M., Chuecos M., Hurley A.E., Li A., Marcovina S.M., Bao G., Boffa M.B., Koschinsky M.L., Lagor W.R. LPA disruption with AAV-CRISPR potently lowers plasma apo(a) in transgenic mouse model: A proof-of-concept study. Mol. Ther. Methods Clin Dev. (2022) Oct 13;27:337-351. PMID: 36381302. PMCID: PMC9630778. *co-first authorship
De Giorgi M.*, Jarrett K.E.*, de Aguiar Vallim T.Q., Lagor W.R. In Vivo Gene Editing in Lipid and Atherosclerosis Research. Methods Mol Biol. (2022) 2419:673-713. PMID: 35237996 *co-first authorship
Doerfler A.M., Han J. Jarrett K.E., Tang L., Jain A., Saltzman A., De Giorgi M., Chuecos M., Hurley A.E., Li A., Morand P., Ayala C., Goodlett D.R., Malovannaya A., Martin J.F., de Aguiar Vallim T.Q., Shroyer N., Lagor W.R. Intestinal Deletion of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Promotes Expansion of the Resident Stem Cell Compartment. Arterioscler Thromb Vasc Biol. (2022) Apr;42(4):381-394. PMID: 35172604. PMCID: PMC8957608
De Giorgi M., Li A., Hurley A., Barzi M. Doerfler A.M., Cherayil N.A., Smith H.E., Brown J.D., Lin C.Y., Bissig K.D., Bao G., Lagor W.R. Targeting the Apoa1 locus for liver-directed gene therapy. Mol Ther Methods Clin Dev. (2021) Apr 24;21:656-669. PMID: 34141821. PMCID: PMC8166646.
De Giorgi M., Jarrett K.E., Burton J.C., Doerfler A.M., Hurley A., Li A., Hsu R.H., Furgurson M., Patel K.R., Han J., Borchers C.H., Lagor W.R. Depletion of essential isoprenoids and ER stress induction following acute liver-specific deletion of HMG-CoA Reductase. J Lipid Res. (2020) Dec;61(12):1675-1686. PMID: 33109681. PMCID: PMC7707164.
Li, A., Tanner, M. R., Lee, C. M., Hurley, A. E., De Giorgi, M., Jarrett, K. E., Davis, T. H., Doerfler, A. M., Bao, G., Beeton, C., and Lagor, W. R. AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9. Mol Ther (2020) 28, 1432-1441. PMID: 32348718; PMCID: PMC7264438.
Li, A., Lee, C. M., Hurley, A. E., Jarrett, K. E., De Giorgi, M., Lu, W., Balderrama, K. S., Doerfler, A. M., Deshmukh, H., Ray, A., Bao, G., and Lagor, W. R. A Self-Deleting AAV-CRISPR System for In Vivo Genome Editing. Mol Ther Methods Clin Dev (2019) 12, 111-122. PMID: 30619914; PMCID: PMC6313841.
Jarrett, K. E., Lee, C., De Giorgi, M., Hurley, A., Gillard, B. K., Doerfler, A. M., Li, A., Pownall, H. J., Bao, G., and Lagor, W. R. Somatic Editing of Ldlr With Adeno-Associated Viral-CRISPR Is an Efficient Tool for Atherosclerosis Research. Arterioscler Thromb Vasc Biol (2018) 38, 1997-2006. PMID: 30026278; PMCID: PMC6202188.
Jarrett, K. E., Lee, C. M., Yeh, Y. H., Hsu, R. H., Gupta, R., Zhang, M., Rodriguez, P. J., Lee, C. S., Gillard, B. K., Bissig, K. D., Pownall, H. J., Martin, J. F., Bao, G., and Lagor, W. R. Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease. Sci Rep (2017) 7, 44624. PMID: 28300165; PMCID: PMC5353616.
Palmer, E. E., Jarrett, K. E., Sachdev, R. K., Al Zahrani, F., Hashem, M. O., Ibrahim, N., Sampaio, H., Kandula, T., Macintosh, R., Gupta, R., Conlon, D. M., Billheimer, J. T., Rader, D. J., Funato, K., Walkey, C. J., Lee, C. S., Loo, C., Brammah, S., Elakis, G., Zhu, Y., Buckley, M., Kirk, E. P., Bye, A., Alkuraya, F. S., Roscioli, T., and Lagor, W. R. Neuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy. Hum Mol Genet (2016) 25, 3042-3054. PMID: 27270415; PMCID: PMC5181598.
