August 1, 2024: We truly appreciate the NIH / NCI for funding our U01 grant with long-time collaborator on "Overcoming Limitations of BET Inhibition in NUT Carcinoma". This generous support will fund research projects to reveal how BRD4-NUT misregulates chromatin to drive tumorigenesis thereby providing insights into new therapies for NUT carcinoma. We are looking forward to exciting results from this project and are excited to by part of the NCI Targeting Fusion Oncoproteins in Childhood Cancers (TFCC) Network!
July 15, 2024: Shuvra Roy joins us from the CSIR-Institute of Genomics and Integrative Biology as a postdoctoral associate! Welcome to the Eagen Lab!
March 11, 2024: Adela Yan and Anna Thommen join us as a graduate students in the Genetics & Genomics Program at 7mÊÓƵ! Welcome to the Eagen Lab!
February 26, 2024: Krupa Sampat joins us from Boston University as a bioinformatics analyst! Welcome to the Eagen Lab!
January 11, 2024: Dr. Kyle Eagen was interviewed for the Epigenetics Podcast by Active Motif! Listen to the podcast to learn about his scientific journey, problems we are currently thinking about, and more !
December 1, 2023: We are excited to have published a collaborative paper with Chris French's lab at Brigham and Women's Hospital in the journal Cancer Research! We identify EZH2, a chromatin regulator that epigenetically silences genes, as a novel vulnerability in NUT carcinoma, that EZH2 suppression of tumor suppressor genes acts in parallel to the activation of oncogenes by the fusion oncoprotein BRD4-NUT, and that combined treatment of mouse models of NUT carcinoma with both an EZH2 inhibitor and a BET inhibitor potently blocks tumor growth and prolongs animal survival. Congratulations to Cate, Chris, and Quan for their contributions to the success of this project! and .
December 1, 2023: Congratulations to the at Brigham and Women's Hospital and Harvard Medical School for their new paper "The BRD4–NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma"! We were happy to contribute to this story! .
November 14, 2023: Dr. Kyle Eagen is grateful and thrilled to receive the Distinguished Scientist Award from The Sontag Foundation. This generous funding will allow the lab to expand into new research areas and determine how fusion oncoproteins that drive aggressive brain tumors alter chromosome 3D structure, nuclear organization, and transcriptional regulation. Read more about this exciting news from the Sontag Foundation and .
April 24, 2023: Ivo Yonchev joins us from the University of Sheffield as a postdoctoral associate! Welcome to the Eagen Lab!
April 18, 2023: Yi-Hung Chen joins us as a graduate student in the Development, Disease Models & Therapeutics Graduate Program at 7mÊÓƵ! Welcome to the Eagen Lab!
January 16, 2023: Dr. Kyle Eagen is grateful to receive an R Accelerated Award from the Alex's Lemonade Stand Foundation (ALSF) for Childhood Cancer. This generous funding will support research projects in the lab about how chromosome 3D structure is reprogrammed in cancer and how to intervene in this reprogramming for therapeutic purposes. Read more about the project on the ALSF and .
November 1, 2022: John Collette joins us as a research associate from a neighboring lab at 7mÊÓƵ. Welcome to the Eagen Lab!
June 6, 2022: Chris Ponne and Quan Le joins us as a research technicians! Chris is from Kenyon College and Quan joins us from Yale University. Welcome to the Eagen Lab!
May 23, 2022: Cate Hawkins joins us from the University of Dayton as a research technician! Welcome to the Eagen Lab!
April 11, 2022: We are thrilled to contribute a news and views article on two new exciting papers in Nature Genetics! Highlights includes how BET proteins, BRD4 in particular, contribute to cohesin-dependent chromatin looping and cohesin-independent genome compartmentalization.
Nov. 17, 2021: Congratulations to the Foltz Lab at Northwestern University for their new paper "UBR7 acts as a histone chaperone for post-nucleosomal histone H3"! We were happy to contribute to this story!
Nov: 1, 2021: We are thrilled to announce that the Eagen Lab has moved to 7mÊÓƵ! We are now members of the Department of Molecular and Cellular Biology and are also affiliated with the Center for Precision Environmental Health, the Stem Cells and Regenerative Medicine Center, and the Center for Cell and Gene Therapy.
Aug.18, 2021: Dr. Kyle Eagen is honored to be awarded a generous First-Time, Tenure-Track Faculty Award from the Cancer Prevention & Research Institute of Texas. This CPRIT grant will allow the lab to pursue high-risk, high-reward projects at the interface of nuclear organization and cancer.
Jan. 15, 2021: Our review with collaborator Chris French at Brigham and Women's Hospital presenting a mechanistic model for how fusion with NUT supercharges BRD4's function as a transcriptional coactivator, including our recent discovery of a novel nuclear subcompartment, is published in Oncogene!
April 2, 2020: We are thrilled to share that the first paper from our lab has been published in Molecular Cell! We're excited to report that we've identified a novel nuclear subcompartment formed by chromatin hyperacetylation. Congratulations to Celeste Rosencrance, Haneen Ammouri, Qi Yu, and Tiffany Ge for their dedication to this project!
Oct, 30, 2019: Our review summarizing the most recent genomics methods to study chromosome architecture is published as a Technology of the Month Article in Trends in Biochemical Sciences! Congratulations to Tiffany Ge and Celeste Rosencrance on the beautiful graphics!
Feb. 1, 2019: Our review, "Principles of Chromosome Architecture Revealed by Hi-C", has been selected as part of the "Best of Trends" series, celebrating reviews published in 2018. Read about the and the .
May 14, 2018: Our lab's review synthesizing recent studies of chromosome architecture using Hi-C is published in Trends in Biochemical Sciences and featured on the cover!
Oct. 5, 2017: Dr. Kyle Eagen is honored to receive a 2017 NIH Director's Early Independence Award and deeply appreciative of the NIH Common Fund for supporting our research!
