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β-´¡³¦³Ù¾±²Ô: ubiquitously expressed cytoplasmic isoform of actin involved in cell structure, cell migration, and embryogenesis. See , , and .

CAG: Artificial construct pairing the chicken ß-actin/rabbit ß-globin hybrid promoter with the human cytomegalovirus enhancer element. Offers high-efficiency ubiquitous expression of transgenic proteins. See and .

CaMKIIα: Calcium-calmodulin kinase IIα, expression limited to neurons of the forebrain; low level expression starts by approx. E18 with maximal expression early postnatal and continuing throughout life.

DAT: Dopamine transporter expressed in ventral midbrain regions including the substantia nigra and ventral tegmental area. Regulates neurotransmission by transporting DA back into presynaptic terminals. See .

GAD2: Glutamic acid decarboxylase 2, gene encodes GAD65, which along with GAD1 encoding GAD67 is responsible for catalyzing production of GABA from L-glutamic acid (). GAD65 protein is primarily found at the axon terminal and produces GABA for synaptic release, while GAD67 is located throughout the cytoplasm and produces GABA used in other processes (). GAD2 is expressed throughout development in GABAergic neurons and in certain non-neuronal cells. See .

Grik4 (KA-1): Ionotropic glutamate receptor responsive to kainate. KA-1 expression is concentrated in the CA3 field of the hippocampus and in dentate gyrus, with lower levels found in other major glutamate-responsive regions such as the inner cortical layers and cerebellar Purkinje cells. See

Nop: Neuropsin (aka Protease Serine 19 (Prss19) or Kallikrein-related peptidase 8 (Klk8)): wild-type Nop is normally expressed in the limbic system of the adult rodent brain, but due to insertion-site dependent effects, expression of TTA in Nop-TTA transgenic mice is limited to superficial layers II and III of medial entorhinal cortex, pre- and parasubiculum. See .

Pcp2: Purkinje cell protein 2 (aka L7 or GPSM4): Gα-interacting protein expressed specifically in Purkinje neurons of the cerebellum and ON bipolar cells in the retina of higher vertebrates. See , , .

POMC: proopiomelanocortin is endogenously expressed in the pituitary gland and in the arcuate nucleus of hypothalamus. Although endogenous POMC is absent in hippocampus, cryptic regions of the POMC promoter that are not required for arcuate and pituitary expression enable expression in immature granule neurons of the dentate gyrus (~ 2 weeks postmitotic) See .

PrP: Prion protein promoter, ubiquitously expressed throughout brain and much of body starting at early embryonic ages and continuing throughout life. See

ROSA26: Ubiquitously expressed locus discovered by retroviral gene trap. Expression is active from early embryonic stages (i.e. morula-blastocyst) through adult. Targeted alleles can be made homozygous without loss-of-function effects. See and .

tetO: Tetracycline-responsive operator, artificial promoter used to drive expression of tetracycline-controlled transgenes, expressed only when tTA is present and tetracycline is not. See . Currently 3 versions of this promoter exist, beginning with the original tetO described by and progressing through the 2010 introduction of tetO-3G by . See also for additional information on the latest promoters, historic evolution, and tetracycline transactivator variants.

Wfs1: Wolfram syndrome 1, encodes the endoplasmic reticulum membrane protein wolframin, involved in ER calcium regulation. Broadly expressed throughout the body, including liver, pancreas, retina, kidney, ovary and testis. Brain distribution is more limited: dorsal hippocampal CA1, caudal striatum (CPu), hypothalamus, nucleus accumbens (NAc) and superficial layers of the entorhinal cortex. See , , .

APP: Amyloid precursor protein, one of only 3 genes associated with inherited autosomal-dominant AD Mutations named for the location of families in which they were identified, i.e. Swedish or Indiana.

Cre: DNA recombinase derived from P1 bacteriophage. Drives site-specific recombination at loxP or similar lox sites. Cre-mediated DNA cleavage between two lox sites results in excision, integration, inversion, or translocation of the intervening sequence depending on the initial orientation and position of the loxP sites. See , , and

CreER^T2: Cytoplasm-localized fusion of the Cre-recombinase and the human estrogen receptor ligand-binding domain. Mutations in the ligand binding domain render the protein insensitive to endogenous estrogens, but retain sensitivity to synthetic antagonist 4-hydroxytamoxifen. On binding tamoxifen, the complex is translocated to the nucleus where cre activates recombination of loxP-flanked DNA. See .

Flp: DNA recombinase from Saccharomyces cerevisiae, catalyzes DNA rearrangement via site-specific cleavage and strand exchange at FRT sites. Similar to Cre, Flp-based recombination results in excision, integration, inversion, or translocation of the intervening DNA depending on the initial orientation of FRT sites. See , , and

GlyCl: Human glycine-gated chloride channel, aka glycine receptor α1, engineered for neuronal silencing with point mutations F207A to reduce glycine sensitivity and A288G to increase ivermectin sensitivity. See .

lox-stop-lox-eYFP: Cre-inducible enhanced YFP reporter. See and .

MAPT: Microtubule-associated protein tau, Axonally-localized microtuble stabilizing protein. Alternate splicing leads to 6 protein isoforms in human (containing 3- or 4-microtubule binding domain repeats) but just 3 isoforms in mice (all 4-repeat). Point mutations in MAPT are associated with autosomal dominant forms of fronto-temporal lobar degeneration and ALS. Transgene used in mice is commonly 4-repeat with P301 missense mutation.

PS1: Presenilin 1, One of 3 genes associated with inherited autosomal-dominant AD, serves as the catalytic subunit of γ-secretase. Mutations named for amino acid changes caused by DNA alterations, such as dE9: exon 9 deletion mutation

TTA: Tetracycline-responsive transactivator, an artificial transcription factor that activates expression from the tetO promoter. Binding of tetracycline to TTA prevents it from activating transcription, thus shutting down expression of the controlled transgene. See and . There are three current tet-off transactivators in use: the original TTA , TTA-2 , and the doxycycline-insensitive variant H100Y . Each of these three bind to all versions of the tetO promoter.

5xFAD Thy1-huAPP^swe/fl/lon;Thy1-huPS1 ^M146L/L286V
Congenic C57BL/6J background: 
Original reference: 

Line PS19 human MAPT P301S
Hybrid B6C3 background:
Original reference:

TMEM106B, 341bp CRISPR deletion
Congenic C57BL/6 background: Kind gift of Fenghua Hu
Original reference: 

TMEM106B, KOMP tm2c allele
Congenic C57BL/6J background: generated by b-actin-Flp mating after IVF resuscitation of KOMP TMEM106B tm2a germplasm at BCM GERM core

Line B CaMKIIα-TTA
Congenic C57BL/6J background:
Hybrid B6/CBA background:
Original reference:
NOTE: This line expresses the original TTA published in .

Line S EC Prss19 (Nop)-TTA
C57BL/6 n3+ backcross: Kind gift of Mark Mayford, Scripps Research Institute (also available through MMRRC: )
Original reference:
NOTE: This line expresses the second-generation TTA-2 published in .

Line ROSA26:LNL:TTA (converts Cre to TTA)
Congenic C57BL/6J background: 
Original reference: 
NOTE: This line expresses a modified version of TTA (mTTA).

Line 102 tetO-APPswe/ind
Congenic C57BL/6J background:
Original reference:

Line 9531 TRE-GlyCl
FVB n8 background:
Original reference:

CX3CR1-CreER^T2-IRES-EYFP
B6 background: Kind gift of Hui Zheng, BCM
Also available on 129B6 through: 
Original reference:  

GAD2-Cre (IRES knock-in)
NOTE: IRES-Cre insertion to 3' UTR of GAD2, impact on GAD2 expression not yet evaluated
Congenic C57BL/6N background:
Original reference:

Thy1-CreER^T2 (transgenic, SLICK-H)
Hybrid CD1:B6 background: 
Original reference: 
See also: 

vGlut1-IRES2-CreD (3' UTR knock-in, Slc17a7-IRES2-Cre-D)
C57BL/6J background:  Kind gift of Russell Ray, BCM
N5 available from Jax: )
Original reference: 

R26-APP (ROSA26-lox-stop-lox-huAPPibe)
Congenic C57BL/6J background: Koller et al., Dis Mod Mech 2022
Available soon from Jax