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Damian Young Lab

Publications

Master
Content

Wach, Jean-Yves; Chamikuri, Srinivas; Sheehan, Patrick; Young, Damian W. 鈥淪tereodivergent strategy toward enantioenriched bicyclic hybrid Csp2-Csp3 fragments鈥, submitted to the Journal of Organic Chemistry.

Young, Damian W. 鈥淐onsiderations Related to Small-molecule Screening Collections鈥 High Throughput Screening Methods: Evolution and Refinement, The Royal Society of Chemistry, in press.

Wang, Yikai; Wach, Jean-Yves; Sheehan, Patrick; Zhong, Cheng; Zhan, Chenyang; Harris, Richard; Almo, Stephan. A.; Bishop. Joshua; Haggarty, Stephan J.; Ramek; Alexander O鈥橦erin, Connor; Koehler, Angela N.; Hung, Alvin W.; Young, Damian W. 鈥Diversity-oriented synthesis as a strategy for fragment evolution against GSK3b鈥 ACS Med. Chem. Lett., 2016, 7, 852-6.

Wang, Yikai; Jimenez, Miguel; Sheehan Patrick; Zhong Cheng; Hung Alvin W., Tam Chung Pong, and Young, Damian W. 鈥淪elective access to trisubstituted macrocyclic E- and Z-alkenes from the ring-closing metathesis of vinylsiloxanes鈥 Org Lett. 2013, 15, 1218-21.

Comins Daniel L., Higuchi Kazuhiro, Young, Damian W. 鈥淒ihydropyridine preparation and application in the synthesis of pyridine derivatives鈥 In Alan R. Katritzky, (ed.), Advances in Heterocyclic Chemistry, Academic Press, 2013, Elsevier Inc., pp.175鈥236.

Yuan, Yuan; Hartland, Kate; Boskovic, Zarko; Wang, Yikai; Walpita, Deepika; Zhong, Cheng; Young Damian W., Kim Young-Kwon, Tolliday Nicola J., Schreiber Stuart L.; and Wagner Bridget K. 鈥淐hemical complementation of Pdx1 causes acquisition of beta cell-like characteristics in a human ductal cell line鈥 Chemistry and Biology, 2013, 12, 1513-22.

Zhong, Cheng; Wang, Yikai; O鈥橦erin, Conor; Young, Damian W. 鈥淪ynthesis of Substituted morpholines using stereodivergent aza-Michael reactions catalyzed by Br酶nsted acids鈥 ACS Catalysis 2013, 3, 643-6.

Zhong, Cheng; Wang, Yikai; Hung, Alvin W., Schreiber, Stuart L.; Young, Damian W. 鈥淒iastereoselective control of intramolecular aza-Michael reactions using achiral catalysts鈥 Org. Lett. 2011,13, 5556-9.

Pandya, Bhaumik A.; Dandapani, Sivaraman; Duvall, Jeremy R.; Rowley, Ann; Mulrooney, Carol A.; Ryba, Troy; Dombrowski, Michael; Harton, Marie; Young, Damian W.; Marcaurelle, Lisa A. 鈥淧ractical asymmetric synthesis of 尾-hydroxy-纬-amino acids via complimentary aldol reactions鈥 Tetrahedron, 2011, 67, 6131-7.

Wang, Yikai; Jimenez, Miguel; Hansen, Anders S., Raiber, Eun-Ang, Schreiber, Stuart L., and Young, Damian W. 鈥淐ontrol of olefin geometry in macrocyclic ring-closing metathesis reactions using a removable silyl group鈥 J. Am. Chem. Soc. 2011, 133, 9196-9.

Marcaurelle, Lisa A.; Comer, Eamon; Dandapani, Sivaraman; Duvall, Jeremy R.; Gerard, Beadouin Kesavan, Sarathy; Lee, Maurice, D.; Liu, Haibo; Lowe, Jason T.; Marie, Jean-Charles; Mulrooney, Carol A.; Pandya, Bhaumik A.; A. Rowley, Ann; Ryba, Troy; Suh, Byung-Chul; Wei, Jingquing; Young, Damian W.; Akella, Lakshmi B.; Ross, Nathan T.; Zhang, Yan-Ling; Fass, Daniel M.; Reis, Surya A.; Zhao, Wen-Ning; Haggarty, Stephen J.; Palmer, Michelle; Foley, Michael A. 鈥 An Aldol-based build/couple/pair strategy for the synthesis of medium-and large sized rings: discovery of macrocyclic histone deacetylase inhibitors鈥 J. Am. Chem. Soc., 2010, 132, 16962-76.

Dancik, Vlado; Seiler, Kathleen, P.; Young, Damian W.; Schreiber, Stuart L. Clemons, Paul A. 鈥淒istinct biological network properties between the targets of natural products and disease genes鈥 J. Am. Chem. Soc. 2010, 132, 9259-61.

Young, Damian W. 鈥淎n Upfront Investment鈥 Nat. Chem. Bio., 2010, 5, 175.

Kelly, Ann W.; Wei, Jingqiang; Kesavan, Sarathy; Marie, Jean-Charles; Windmon, Nicole; Young, Damian W. and Marcaurelle, Lisa A. 鈥淎ccessing skeletal diversity using catalyst control: formation of n and n+1 macrocyclic triazole rings鈥 Org. Lett. 2009,11, 2257-60.