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Matern, M.S., Durruthy-Durruthy, R., Birol, O., Darmanis, S., Scheibinger, M., Groves, A.K. and Heller, S. (2023). Transcriptional dynamics of delaminating neuroblasts in the mouse otic vesicle. Cell Reports, in press

Mao, K., Borel, C., Ansar, M., Jolly, A., Makrythanasis, P., Froehlich, C., Iwaszkiewicz, J., Wang, B., Xu, X., Blanc, X., Cai, J., Chen, Q., Ankamreddy, H., Singh, S., Zhang, H., Wang, X., Zhao, S., Ranza, E., Paracha, S.A., Syed, F.S., Guida, V., Piceci-Sparascio, F., Melis, D., Dallapiccola, B., Digilio, M.C., Novelli, A, Magliozzi, M, Fadda, M.T., Streff, H., Machol, K., Lewis, R.A., Zoete, V., Squelo, G.M., Prontera, P., Mancano, G., Gori, G., Mariani, M., Selicorni, A., Psoni, S., Fryssira, H., Cox, T.C., Douzgou, S., Marlin, S., Biskup, S., DeLuca, A., Merla, G., Groves, A.K., Lupski, J.R., Zhang, Q., Zhang, Y.-B., and Antonarakis, S.E. (2023). FOXI3 pathogenic variants cause one form of craniofacial microsomia.

McGovern, M.M., Hartman, B.H., Thawani, A., Maunsell, H.R., Zhang, H., Yousaf, R., Heller, S., Stone, J.S. and Groves, A.K. (2022). Fbxo2CreERT2 is expressed in the cochlear duct and vestibular organs in the mouse inner ear.

Iyer, A., Hosamani, I., Nguyen, J.D., Cai, T., Singh, S., McGovern, M.M., Beyer, L.A., Zhang, H., Jen, H.-I, Yousaf, R., Birol, O., Sun, J., Ray, R.S., Raphael, Y., Segil, N. and Groves, A.K. (2022). Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals.

Ghosh, R., Bosticardo, M., Singh, S., Similuk, M., Delmonte, O.M., Pala, F., Peng, C., Jodarski, C., Keller, M.D., Chinn, I., Groves, A.K., Notarangelo, L.D., Walkiewicz, M. A., Chinen, J. and Bundy, V. (2022). FOXI3 haploinsufficiency contributes to low T cell receptor excision circles and T cell lymphopenia. 

Tang, P.-C., Chen, L., Singh, S., Groves, A.K., Koehler, K.R., Liu, X.Z., and Nelson, R. (2022). Wnt signaling promotes cell caudalization  in mouse stem cell-derived organoids.

Jen, H.-I, Singh, S., Tao, L., Yu, H., Segil, N. and Groves, A.K. (2022). GFI1 regulates hair cell differentiation by acting as an off-DNA transcriptional co-activator of ATOH1, and a DNA-binding repressor.

Li, H., Janssens, J., De Waegeneer, M., Kolluru, S.S., [….] FCA Consortium, Jasper, H., Oliver, B., Perrimon, N., Deplancke, B., Quake, S.R., Luo, L., and Aerts, S. (2022). Fly Cell Atlas: a single-cell transcriptomic atlas of the adult fruit fly. 

Akdemir, E, Woo, J., Bosquez Huerta, N.A., Lozzi, B., Groves, A.K., Harmanci, A., and Deneen, B. (2021). Lunatic Fringe-GFP marks lamina-specific astrocytes that regulate sensory processing.

Huang, T.-W., Iyer, A.I, Manalo, J.M., Woo, J., Bosquez Huerta, N.A., McGovern, M.M., Schrewe, H., Pereira, F.A., Groves, A.K., Ohlemiller, K.K. and Deneen, B. (2021). Glial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis.

Tao, L., Yu, H., Llamas, J., Trecek, T., Wang, X., Stojanova, Z., Groves, A.K. and Segil, N. (2021). Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration.

Lee, S., Song, J.-J., Beyer, L.A., Swiderski, D.L., Prieskorn, D.M., Acar, M., Jen, H.-I, Groves, A.K. and Raphael, Y. (2020). Combinatorial Atoh1 and Gfi1 induction enhances hair cell regeneration in the adult cochlea.

Gnedeva, K., Wang, X., McGovern, M.M., Barton, M., Tao, L., Trecek, T., Monroe, T.O., Llamas, J., Makmura, W., Martin, J.F., Groves, A.K., Warchol, M., and Segil, N. (2020). Organ of Corti size is governed by Yap/Tead-mediated progenitor self-renewal.

Brown, R.M., Nelson, J.C., Zhang, H., Kiernan, A.E., and Groves, A.K. (2020). Notch-mediated lateral induction is necessary to maintain vestibular prosensory identity during inner ear development.

Bernstock, J.D., Totten, A.H., Elkahloun, A.G., Johnson, K.R., Hurst, A.C., Goldman, F., Groves, A.K., Fady, M.M. and Atkinson, T.P. (2020). Recurrent microdeletions at chromosome 2p11.2 are associated with thymic hypoplasia and features resembling DiGeorge Syndrome.

Jen, H.-I, Hill, M.C., Tao, L., Sheng, K., Cao, W., Zhang, H., Yu, H.V., Llamas, J., Zong, C., Martin, J.F., Segil, N. and Groves, A.K. (2019). Transcriptomic and epigenetic regulation of hair cell regeneration in the mouse utricle and its potentiation by Atoh1 . eLife, e44328. doi: 10.7554/eLife.44328

Singh, S., Jangid, R.K., Crowder, A. and Groves, A.K. (2018). Foxi3 transcription factor activity is mediated by a C-terminal transactivation domain and regulated by the Protein Phosphatase 2A (PP2A) complex.

Xie, W., Jen, H.-I, Seymour, M., Yeh, S.-Y., Pereira, F., Groves, A.K., Klisch, T., and Zoghbi, H.Y. (2017). An Atoh1-S193A phospho-mutant allele causes hearing deficits and motor impairment.

Semerci, F., Choi, W. T.-S, Bajic, A., Thakkar, A., Encinas, J.M., Depreux, F., Segil, N., Groves, A.K. and Maletic-Savatic, M. (2017). Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance.

Basch, M.L., Brown, R.M., Jen, H.-I, Semerci, F., Depreux, F., Edlund, R.K., Zhang, H., Norton, C.R., Gridley, T., Cole, S.E., Doetzlhofer, A., Maletic-Savatic, M., Segil, N. and Groves, A.K. (2016). Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates.

Maass, J.C., Gu, R., Cai, T., Wan, Y.-W., Cantellano, S.C., Asprer, J.S.T., Zhang, H., Jen, H.-I, Edlund, R.K., Liu, Z. and Groves, A.K. (2016). Transcriptomic analysis of mouse cochlear supporting cell maturation reveals large-scale changes in Notch responsiveness prior to the onset of hearing. RNA-seq files can be downloaded from GEO

Li, T., Giagtzoglou, N., Eberl, D.F., Jaiswal, S.N., Jaiswal, M., Cai., T., Godt, D., Groves, A.K. and Bellen, H.J. (2016). The E3 ligase Ubr3 regulates Usher syndrome and MYH9-related disorder proteins in the auditory organs of Drosophila and mammals.

Li, T., Fan, J., Blanco-Sanchez, B., Giagtzoglou, N., Lin, G., Yamamoto, S., Jaiswal, M., Chen, K., Zhang, J., Wei, W., Lewis, M., Groves, A.K. , Westerfield, M., Jia, J., and Bellen, H.J. (2016). Ubr3, a novel modulator of Hh signaling affects the degradation of Costal-2 and Kif7 through poly-ubiquitination.

Gu, R., Brown, R.M., Hsu, C.-W., Crowder, A., Piazza, V.G., Vadakkan, T.J., Cai, T., Dickinson, M.E. and Groves, A.K. (2016). Lineage tracing of Sox2-expressing progenitor cells in the mouse inner ear reveals a broad contribution to non-sensory tissues and insights into the origin of the organ of Corti.

Shirokova, V., Jussila, M., Biggs, L.C., Ohyama, T., Groves, A.K. and Mikkola, M.L. (2016). Foxi3 deficiency compromises hair follicle stem cell specification and activation.

Birol, O., Ohyama, T., Edlund, R.K., Drakou, K., Georgiades, P., and Groves, A.K. (2015). The mouse Foxi3 transcription factor is necessary for the development of posterior placodes.

Jussila, M., Aalto, A., Sanz Navarro, M., Shirokova, V., Kallonen, A., Ohyama, T., Groves, A.K., Mikkola, M.L. and Thesleff, I. (2015). Suppression of epithelial differentiation by Foxi3 is essential for molar crown patterning. .

Maass, J.C., Gu, R., Basch, M.L., Waldhaus, J., Martin-Lopez, E., Xia, A., Oghalai, J.S., Heller, S. and Groves, A.K. (2015). Changes in the regulation of the Notch signaling pathway are temporally correlated with regenerative failure in the mouse cochlea. .

Kantarci, H., Edlund, R.K., Groves, A.K. and Riley, B.B. (2015). Tfap2a promotes specification and maturation of neurons in the inner ear through modulation of BMP, FGF and Notch signaling.

Cai, T., Jen, H.-I, Kang, H., Klisch, T.J., Zoghbi, H.Y and Groves, A.K. (2015). Characterization of the transcriptome of nascent hair cells and identification of direct targets of the Atoh1 transcription factor. (Supplementary data for Cai et al. (2015) can be downloaded here. , , , , , , . RNA-seq files can be downloaded from GEO )

Tassano, E., Jagannathan, V., Drögemüller, C., Leoni, M., Hytönen, M., Severino, M., Gimelli, S., Cuoco, C., Di Rocco, M., Sanio, K., Groves, A.K., Leeb, T and Gimelli, G. (2015). Congenital aural atresia associated with agenesis of internal carotid artery in a girl with a FOXI3 deletion.

Gao, S.S., Wang, R., Raphael, P.D., Moayedi, Y., Groves, A.K., Zuo, J., Applegate, B.E. and Oghalai, J.S. (2014). Sharp frequency tuning within the mammalian cochlea does not require active processes.

Khatri, S.B., Edlund, R.K. and Groves, A.K. (2014) Foxi3 is necessary for the induction of the chick otic placode in response to FGF signaling. .

Edlund, R.K., Ohyama, T., Kantarci, H., Riley, B.B. and Groves, A.K. (2014). Foxi transcription factors promote pharyngeal arch development by regulating the formation of FGF signaling centers.

Moayedi, Y., Basch, M.L., Pacheco, N., Gao, S.G., Harrison, W., Xioa, N, Oghalai, J.S., Overbeek, P.A., Mardon G., and Groves A.K. (2014). The splicing factor Sfswap regulates growth and patterning of inner ear sensory organs.

Xia A., Song, Y., Wang, R., Gao, S., Clifton, W., Raphael, P., Cho, S.-I., Pereira, F., Groves, A.K. and Oghalai, J.S. (2013). Prestin regulation and function in residual outer hair cels after noise-induced hearing loss.

Cai, T, Seymour, M.L., Zhang, H., Pereira, F. A. and Groves, A.K. (2013). Conditional deletion of Atoh1 reveals distinct critical periods for survival and function of hair cells in the organ of Corti. 33, 10110-10122.

Yang, L., O’Neill, P., Martin, K., Maass, J.C., Vassilev, V., Ladher, R. and Groves, A.K. (2013). Analysis of FGF-dependent and FGF-independent pathways in otic placode induction.

Khatri, S.B. and Groves, A.K. (2013). Expression of Foxi2 and Foxi3 transcription factors during development of chicken sensory placodes and pharyngeal arches.

White, P.M., Stone, J.S., Groves, A.K. and Segil, N. (2012). EGFR signaling is required for regenerative proliferation in the cochlea: Conservation in birds and mammals.

Basch, M.L., Ohyama, T., Segil, N. and Groves, A.K. (2011). Canonical Notch signaling is not necessary for prosensory induction in the mouse cochlea: Insights from a conditional mutant of RBPjk. .

Reginesi, A., Clarkson, M., Neirjnck, Y., Lu, B., Ohyama, T., Groves, A.K., Sock, E., Wegner, M., Costantini, F., Charboissier, M.C. and Schedl, A (2011). Sox9 controls epithelial branching by activating RET effector genes during kidney development. .

Ohyama, T., Basch, M.L., Mishina, Y., Lyons, K., Segil, N., and Groves, A.K. (2010). BMP signaling is necessary for patterning the sensory and non-sensory regions of the developing mammalian cochlea. .

Doetzlhofer, A., Basch, M.L., Ohyama, T., Gessler, M., Groves, A.K. and Segil, N. (2009). Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti..

Jayasena, C.S., Ohyama, T., Segil, N. and Groves, A.K. (2008). Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode. .

Raft, S., Koundakjian, E.J., Quinones, H., Jayasena, C.S., Goodrich, L.V., Johnson, J.E., Segil, N. and Groves, A.K. (2007). Cross-regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development. .

Doetzlhofer, A., White, P.M., Lee, Y.-S., Groves, A.K. and Segil, N. (2006). Prospective identification and purification of hair cell and supporting cell progenitors from the embryonic cochlea.

White, P.M., Doetzlhofer, A., Lee, Y.-S., Groves, A.K. and Segil, N. (2006). Cochlear supporting cells retain the ability to divide and transdifferentiate into sensory hair cells.

Arnold, J.S., Braunstein, E.M., Ohyama, T., Groves, A.K., Adams, J.C., Brown, M.C. and Morrow, B.E. (2006). Tissue specific roles of Tbx1 in the development of the outer, middle and inner ear, defective in 22q11DS patients.

Ohyama, T., Mohamed, O.A., Taketo, M.M., Dufort, D. and Groves, A.K. (2006). Wnt signals mediate a fate decision between otic placode and epidermis.

Martin, K. and Groves, A.K. (2006). Competence of cranial ectoderm to respond to FGF signaling suggests a two step model of otic placode induction.

Kil, S.-H., Streit, A., Brown, S.T., Agrawal, N., Collazo, A., Zile, M.H. and Groves, A.K. (2005). Distinct roles for hindbrain and paraxial mesoderm in the induction and patterning of the inner ear revealed by a study of vitamin A-deficient quail.

Brown, S.P., Wang, J. and Groves, A.K. (2005). Dlx gene expression during chick inner ear development.

Doetzlhofer, A., White, P.M., Johnson, J.E., Segil, N. and Groves, A.K. (2004). In vitro growth and differentiation of mammalian sensory hair cell progenitors: A requirement for EGF and periotic mesenchyme.

Ohyama, T., and Groves, A.K. (2004a). Generation of Pax2-Cre mice by modification of a Pax2 bacterial artificial chromosome.

Ohyama, T. and Groves, A.K. (2004b). Expression of mouse Foxi class genes in early craniofacial development.

Lumpkin, E.A., Collisson, T., Parab, P., Omer-Abdalla, A., Haeberle, H., Chen, P., Doetzlhofer, A., White, P., Groves, A., Segil, N., and Johnson, J.E. (2003). Math1-driven GFP expression in the developing nervous system of transgenic mice.

Groves, A.K. and Bronner-Fraser, M. (2000). Competence, specification and commitment in otic placode induction.

McGovern, M.M. and Groves, A.K. (2023). Specification and Plasticity of Cochlear Hair Cell Progenitors. In “Hair Cell Regeneration” () J.S. Stone, M.A. Warchol, A. N. Popper, R.R. Fay, eds. (New York, Springer Verlag).

Iyer, A.A. and Groves, A.K. (2021). Transcription factor reprogramming in the inner ear: Turning on cell fate switches to regenerate sensory hair cells.

Thawani, A. and Groves, A.K. (2020). Building the Border: Development of the Chordate Neural Plate Border Region and its Derivatives..

Ankamreddy, H., Bok, J. and Groves, A.K. (2020). Uncovering the secreted signals and transcription factors regulating the development of mammalian middle ear ossicles. .

Brown, R.M. and Groves, A.K. (2020). Hear, hear for Notch: Control of cell fates in the inner ear by Notch signaling.

Li, T., Bellen, H.J. and Groves, A.K. (2018). Using Drosophila to study mechanisms of hereditary hearing loss.

Groves, A.K. and Fekete, D.M. (2017). New Directions in Cochlear Development. In “Understanding the Cochlea” () G. A. Manley, A.W. Gummer, A. N. Popper, R.R. Fay, eds. (New York, Springer Verlag).

Singh, S., and Groves, A.K. (2016). The molecular basis of craniofacial placode development.

Basch, M.L., Brown, R.M., Jen, H.-I and Groves, A.K. (2016). Where hearing starts: The development of the mammalian cochlea.

Edlund, R.K., Birol, O. and Groves, A.K. (2015). The role of Foxi family transcription factors in the development of the ear and jaw.

Raft, S. and Groves, A.K. (2015). Segregating neural and mechanosensory fates at the developing ear: patterning, signaling, and transcriptional control.

Cai, T. and Groves, A.K. (2015). The role of Atonal factors in mechanosensory cell specification and function.

Gridley, T. and Groves, A.K. (2014). Overview of genetic tools and techniques to study Notch signaling in mice.

Groves, A.K., and LaBonne, C. (2014): Setting appropriate boundaries: Fate, patterning and competence at the neural plate border.

Groves, A.K., Zhang, K.D., and Fekete, D.M. (2013). The genetics of hair cell development and regeneration.

Jarman, A.P. and Groves, A.K. (2013). The role of atonal transcription factors in the development of mechanosensitive cells.

Groves, A.K. and Fekete, D.M. (2012). Shaping sound in space: The regulation of inner ear patterning.

Groves, A.K. (2010). The challenge of hair cell regeneration.

Ohyama, T., Groves, A.K., and Martin, K. (2007). The first steps towards hearing: Mechanisms of otic placode induction.

Groves, A. K. (2005). The induction of the otic placode. In “Development of the Inner Ear” () A. N. Popper, M. W. Kelley, and D. K. Wu, eds. (New York, Springer Verlag).

Brown, S.P., Martin K., and Groves, A.K. (2003). Molecular basis of inner ear induction.