Successful IMSD students publish one or more research articles upon graduation.
Publications Highlights (2024 articles)
Perez GA, Park KW, Lanza D, Cicardo J, Uddin MD, Jankowsky JL. Generation of a Dcx-CreER T2 knock-in mouse for genetic manipulation of newborn neurons. Genesis. 2024 Feb;62(1): e23584. doi: 10.1002/dvg.23584. Epub 2023 Dec 16. PMID: 38102875; PMCID: PMC11021165.
Joseph FM, Young NL. Histone variant-specific post-translational modifications. Semin Cell Dev Biol. 2023 Feb 15; 135:73-84. doi: 10.1016/j.semcdb.2022.02.012. Epub 2022 Mar 9. PMID: 35277331; PMCID: PMC9458767.
Phillips M, Malone KL, Boyle BW, Montgomery C, Kressy IA, Joseph FM, Bright KM, Boyson SP, Chang S, Nix JC, Young NL, Jeffers V, Frietze S, Glass KC. Impact of Combinatorial Histone Modifications on Acetyllysine Recognition by the ATAD2 and ATAD2B Bromodomains. J Med Chem. 2024 May 23;67(10):8186-8200. doi: 10.1021/acs.jmedchem.4c00210. Epub 2024 May 11. PMID: 38733345; PMCID: PMC11149620.
Halpert MM, Burns BA, Rosario SR, Withers HG, Trivedi AJ, Hofferek CJ, Gephart BD, Wang H, Vazquez-Perez J, Amanya SB, Hyslop ST, Yang J, Kemnade JO, Sandulache VC, Konduri V, Decker WK. Multifactoral immune modulation potentiates durable remission in multiple models of aggressive malignancy. FASEB J. 2024 May 31;38(10): e23644. doi: 10.1096/fj.202302675R. PMID: 38738472.
Bijou I, Liu Y, Lu D, Chen J, Sloan S, Alinari L, Lonard DM, O'Malley BW, Wang M, Wang J. Inhibition of SRC-3 as a potential therapeutic strategy for aggressive mantle cell lymphoma. PLoS One. 2024 Apr 29;19(4): e0289902. doi: 10.1371/journal.pone.0289902. PMID: 38683834; PMCID: PMC11057735.
Lu D, Chen J, Qin L, Bijou I, Yi P, Li F, Song X, MacKenzie KR, Yu X, Yang B, Roy Chowdhury S, Korp JD, O'Malley BW, Lonard DM, Wang J. Lead Compound Development of SRC-3 Inhibitors with Improved Pharmacokinetic Properties and Anticancer Efficacy. J Med Chem. 2024 Apr 11;67(7):5333-5350. doi: 10.1021/acs.jmedchem.3c01596. Epub 2024 Mar 29. PMID: 38551814; PMCID: PMC11105966.
Bijou I, Liu Y, Lu D, Chen J, Sloan S, Alinari L, Lonard DM, O'Malley BW, Wang M, Wang J. Inhibition of SRC-3 as a potential therapeutic strategy for aggressive mantle cell lymphoma. Res Sq [Preprint]. 2023 Mar 10: rs.3.rs-2653461. doi: 10.21203/rs.3.rs-2653461/v1. Update in: PLoS One. 2024 Apr 29;19(4): e0289902. PMID: 36945511; PMCID: PMC10029087.
Hao X, Shen Y, Chen N, Zhang W, Valverde E, Wu L, Chan HL, Xu Z, Yu L, Gao Y, Bado I, Michie LN, Rivas CH, Dominguez LB, Aguirre S, Pingel BC, Wu YH, Liu F, Ding Y, Edwards DG, Liu J, Alexander A, Ueno NT, Hsueh PR, Tu CY, Liu LC, Chen SH, Hung MC, Lim B, Zhang XH. Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal. Cell Stem Cell. 2023 May 4;30(5):648-664.e8. doi: 10.1016/j.stem.2023.04.005. PMID: 37146584; PMCID: PMC10165729.
Adewunmi O, Shen Y, Zhang XH, Rosen JM. Targeted Inhibition of lncRNA Malat1 Alters the Tumor Immune Microenvironment in Preclinical Syngeneic Mouse Models of Triple-Negative Breast Cancer. Cancer Immunol Res. 2023 Nov 1;11(11):1462-1479. doi: 10.1158/2326-6066.CIR-23-0045. PMID: 37603945; PMCID: PMC10618655.
Qiu L, Chirman D, Clark JR, Xing Y, Hernandez Santos H, Vaughan EE, Maresso AW. Vaccines against extraintestinal pathogenic Escherichia coli (ExPEC): progress and challenges. Gut Microbes. 2024 Jan-Dec;16(1):2359691. doi: 10.1080/19490976.2024.2359691. Epub 2024 Jun 2. PMID: 38825856; PMCID: PMC11152113.
Carter H, Clark J, Carlin LG, Vaughan E, Rajan A, Olvera A, Yu X, Zeng XL, Kambal A, Holder M, Qin X, Gibbs RA, Petrosino JF, Muzny DM, Doddapaneni H, Menon VK, Hoffman KL, Meng Q, Ross MC, Javornik Cregeen SJ, Metcalf G, Jenq R, Blutt S, Estes MK; TMC-GCID team; Maresso A, Okhuysen PC. Functional Genomics of Gastrointestinal Escherichia coli Isolated from Patients with Cancer and Diarrhea. bioRxiv [Preprint]. 2023 Jun 1:2023.05.31.543115. doi: 10.1101/2023.05.31.543115. PMID: 37398483; PMCID: PMC10312547.
Burg MF, Zenkel T, Vystr膷ilov谩 M, Oesterle J, H枚fling L, Willeke KF, Lause J, M眉ller S, Fahey PG, Ding Z, Restivo K, Sridhar S, Gollisch T, Berens P, Tolias AS, Euler T, Bethge M, Ecker AS. Most discriminative stimuli for functional cell type clustering. ArXiv [Preprint]. 2024 Mar 14: arXiv:2401.05342v2. PMID: 38560735; PMCID: PMC10980086.
Cadena SA, Willeke KF, Restivo K, Denfield G, Sinz FH, Bethge M, Tolias AS, Ecker AS. Diverse task-driven modeling of macaque V4 reveals functional specialization towards semantic tasks. PLoS Comput Biol. 2024 May 23;20(5): e1012056. doi: 10.1371/journal.pcbi.1012056. PMID: 38781156; PMCID: PMC11115319.
Mendoza A, Patel P, Robichaux D, Ramirez D, Karch J. Inhibition of the mPTP and Lipid Peroxidation Is Additively Protective Against I/R Injury. Circ Res. 2024 May 10;134(10):1292-1305. doi: 10.1161/CIRCRESAHA.123.323882. Epub 2024 Apr 15. PMID: 38618716; PMCID: PMC11081482.
Lewis MA, Cort茅s-Penfield NW, Ettayebi K, Patil K, Kaur G, Neill FH, Atmar RL, Ramani S, Estes MK. Standardization of an antiviral pipeline for human norovirus in human intestinal enteroids demonstrates nitazoxanide has no to weak antiviral activity. Antimicrob Agents Chemother. 2023 Oct 18;67(10): e0063623. doi: 10.1128/aac.00636-23. Epub 2023 Oct 3. PMID: 37787556; PMCID: PMC10583671.
Kemnade JO, Florez M, Sabichi A, Zhang J, Jhaveri P, Chen G, Chen A, Miller- Chism C, Shaun B, Hilsenbeck SG, Hernandez DJ, Skinner HD, Sandulache VC. Phase I / II trial of metformin as a chemo-radiosensitizer in a head and neck cancer patient population. Oral Oncol. 2023 Oct; 145:106536. doi: 10.1016/j.oraloncology.2023.106536. Epub 2023 Aug 8. PMID: 37562095.
Masschelin PM, Saha P, Ochsner SA, Cox AR, Kim KH, Felix JB, Sharp R, Li X, Tan L, Park JH, Wang L, Putluri V, Lorenzi PL, Nuotio-Antar AM, Sun Z, Kaipparettu BA, Putluri N, Moore DD, Summers SA, McKenna NJ, Hartig SM. Vitamin B2 enables regulation of fasting glucose availability. Elife. 2023 Jul 7;12: e84077. doi: 10.7554/eLife.84077. PMID: 37417957; PMCID: PMC10328530.
Felix JB, Saha PK, de Groot E, Tan L, Sharp R, Anaya ES, Li Y, Quang H, Saidi N, Abushamat L, Ballantyne CM, Amos CI, Lorenzi PL, Klein S, Gao X, Hartig SM. N-acetylaspartate from fat cells regulates postprandial body temperature. Res Sq [Preprint]. 2024 Jan 9: rs.3.rs-3835159. doi: 10.21203/rs.3.rs-3835159/v1. PMID: 38260478; PMCID: PMC10802732.
Erice PA, Huang X, Seasock MJ, Robertson MJ, Tung HY, Perez-Negron MA, Lotlikar SL, Corry DB, Kheradmand F, Rodriguez A. Downregulation of Let-7 miRNA promotes Tc17 differentiation and emphysema via de-repression of ROR纬t. bioRxiv [Preprint]. 2024 Mar 4:2023.10.12.562059. doi: 10.1101/2023.10.12.562059. Update in: Elife. 2024 May 09;13: PMID: 37905101; PMCID: PMC10614797.
Wu Y, Adeniyi-Ipadeola G, Adkins-Threats M, Seasock M, Suarez-Reyes C, Fujiwara R, Bottazzi ME, Song L, Mills JC, Weatherhead JE. Host gastric corpus microenvironment facilitates Ascaris suum larval hatching and infection in a murine model. PLoS Negl Trop Dis. 2024 Feb 7;18(2): e0011930. doi: 10.1371/journal.pntd.0011930. PMID: 38324590; PMCID: PMC10878500.
Erice PA, Huang X, Seasock MJ, Robertson MJ, Tung HY, Perez-Negron MA, Lotlikar SL, Corry DB, Kheradmand F, Rodriguez A. Downregulation of Mirlet7 miRNA family promotes Tc17 differentiation and emphysema via de- repression of ROR纬t. Elife. 2024 May 9;13:RP92879. doi: 10.7554/eLife.92879. PMID: 38722677; PMCID: PMC11081633.
Seasock MJ, Shafiquzzaman M, Ruiz-Echartea ME, Kanchi RS, Tran BT, Simon LM, Meyer MD, Erice PA, Lotlikar SL, Wenlock SC, Ochsner SA, Enright A, Carisey AF, Romero F, Rosas IO, King KY, McKenna NJ, Coarfa C, Rodriguez A. Let-7 restrains an oncogenic epigenetic circuit in AT2 cells to prevent ectopic formation of fibrogenic transitional cell intermediates and pulmonary fibrosis. bioRxiv [Preprint]. 2024 May 27:2024.05.22.595205. doi: 10.1101/2024.05.22.595205. PMID: 38826218; PMCID: PMC11142151.
Mercado-Evans V, Mejia ME, Zulk JJ, Ottinger S, Hameed ZA, Serchejian C, Marunde MG, Robertson CM, Ballard MB, Ruano SH, Korotkova N, Flores AR, Pennington KA, Patras KA. Gestational diabetes augments group B Streptococcus infection by disrupting maternal immunity and the vaginal microbiota. Nat Commun. 2024 Feb 3;15(1):1035. doi: 10.1038/s41467-024-45336-6. PMID: 38310089; PMCID: PMC10838280.
Mejia ME, Mercado-Evans V, Zulk JJ, Ottinger S, Ruiz K, Ballard MB, Fowler SW, Britton RA, Patras KA. Vaginal microbial dynamics and pathogen colonization in a humanized microbiota mouse model. NPJ Biofilms Microbiomes. 2023 Nov 20;9(1):87. doi: 10.1038/s41522-023-00454-9. PMID: 37985659; PMCID: PMC10661851.
Mercado-Evans V, Chew C, Serchejian C, Saltzman A, Mejia ME, Zulk JJ, Cornax I, Nizet V, Patras KA. Tamm-Horsfall protein augments neutrophil NETosis during urinary tract infection. bioRxiv [Preprint]. 2024 Feb 5:2024.02.01.578501. doi: 10.1101/2024.02.01.578501. PMID: 38370726; PMCID: PMC10871275.
Fernandez-Sanchez J, Rodgers R, Maknojia AA, Shaikh N, Yan H, Mejia ME, Hendricks H, Jenq RR, Reddy P, Banerjee R, Schraw JM, Baldridge MT, King KY. Antibiotic-associated neutropenia is marked by depletion of intestinal Lachnospiraceae in pediatric patients. medRxiv [Preprint]. 2024 Apr 27:2024.04.25.24306386. doi: 10.1101/2024.04.25.24306386. PMID: 38712139; PMCID: PMC11071563.
Kardian AS, Mack S. The Intersection of Epigenetic Alterations and Developmental State in Pediatric Ependymomas. Dev Neurosci. 2024 Mar 25. doi: 10.1159/000537694. Epub ahead of print. PMID: 38527429.
Emig AA, Hansen M, Grimm S, Coarfa C, Lord ND, Williams MK. Temporal dynamics of BMP/Nodal ratio drive tissue-specific gastrulation morphogenesis. bioRxiv [Preprint]. 2024 Feb 7:2024.02.06.579243. doi: 10.1101/2024.02.06.579243. PMID: 38370754; PMCID: PMC10871350.
Adeniyi-Ipadeola G, Nwanosike H, Ramani S. Human intestinal organoids as models to study enteric bacteria and viruses. Curr Opin Microbiol. 2023 Oct; 75:102362. doi: 10.1016/j.mib.2023.102362. Epub 2023 Aug 1. PMID: 37536261; PMCID: PMC10529792.
Adeniyi-Ipadeola GO, Hoffman KL, Yang H, Javornik Cregeen SJ, Preidis GA, Ramani S, Hair AB. Human milk cream alters intestinal microbiome of preterm infants: a prospective cohort study. Pediatr Res. 2024 May;95(6):1564-1571. doi: 10.1038/s41390-023-02948-w. Epub 2024 Jan 16. PMID: 38228744.
Adeniyi-Ipadeola GO, Hankins JD, Kambal A, Zeng XL, Patil K, Poplaski V, Bomidi C, Nguyen-Phuc H, Grimm SL, Coarfa C, Stossi F, Crawford SE, Blutt SE, Speer AL, Estes MK, Ramani S. Infant and Adult Human Intestinal Enteroids are Morphologically and Functionally Distinct. bioRxiv [Preprint]. 2024 Feb 17:2023.05.19.541350. doi: 10.1101/2023.05.19.541350. PMID: 37292968; PMCID: PMC10245709.
Wu Y, Adeniyi-Ipadeola G, Adkins-Threats M, Seasock M, Suarez-Reyes C, Fujiwara R, Bottazzi ME, Song L, Mills JC, Weatherhead JE. Host gastric corpus microenvironment facilitates Ascaris suum larval hatching and infection in a murine model. PLoS Negl Trop Dis. 2024 Feb 7;18(2): e0011930. doi: 10.1371/journal.pntd.0011930. PMID: 38324590; PMCID: PMC10878500.
Watts J, Taylor K. Gentrification increases risk of tick-borne disease for communities of colour. Nat Microbiol. 2024 Feb;9(2):312-313. doi: 10.1038/s41564-023-01590-w. PMID: 38316921.
Sobhani N, Tardiel-Cyril DR, Chai D, Generali D, Li JR, Vazquez-Perez J, Lim JM, Morris R, Bullock ZN, Davtyan A, Cheng C, Decker WK, Li Y. Artificial intelligence-powered discovery of small molecules inhibiting CTLA-4 in cancer. BJC Rep. 2024; 2:4. doi: 10.1038/s44276-023-00035-5. Epub 2024 Jan 23. PMID: 38312352; PMCID: PMC10838660.
Xu Z, Liu F, Ding Y, Pan T, Wu YH, Liu J, Bado IL, Zhang W, Wu L, Gao Y, Hao X, Yu L, Edwards DG, Chan HL, Aguirre S, Dieffenbach MW, Chen E, Shen Y, Hoffman D, Dominguez LB, Rivas CH, Chen X, Wang H, Gugala Z, Satcher RL, Zhang XH. Unbiased metastatic niche-labeling identifies estrogen receptor-positive macrophages as a barrier of T cell infiltration during bone colonization. bioRxiv [Preprint]. 2024 May 10:2024.05.07.593016. doi: 10.1101/2024.05.07.593016. PMID: 38765966; PMCID: PMC11100675.
Brown AM, Lackey EP, Salazar Leon LE, Rey Hipolito AG, Beckinghausen J, Lin T, Sillitoe RV. Electromyography as a Method for Distinguishing Dystonia in Mice. Adv Neurobiol. 2023;31:71-91. doi: 10.1007/978-3-031-26220-3_5. PMID: 37338697.
Melton AJ, Palfini VL, Ogawa Y, Rasband MN. TRIM46 is not required for axon specification or axon initial segment formation in vivo. bioRxiv [Preprint]. 2024 May 23:2024.05.23.595556. doi: 10.1101/2024.05.23.595556. PMID: 38826451; PMCID: PMC11142202.
Konecki DM, Hamrick S, Wang C, Agosto MA, Wensel TG, Lichtarge O. CovET: A covariation-evolutionary trace method that identifies protein structure-function modules. J Biol Chem. 2023 Jul;299(7):104896. doi: 10.1016/j.jbc.2023.104896. Epub 2023 Jun 7. PMID: 37290531; PMCID: PMC10338321.
Si H, Esquivel M, Mendoza Mendoza E, Roarty K. The covert symphony: cellular and molecular accomplices in breast cancer metastasis. Front Cell Dev Biol. 2023 Jun 27; 11:1221784. doi: 10.3389/fcell.2023.1221784. PMID: 37440925; PMCID: PMC10333702.
Zboril EK, Grible JM, Boyd DC, Hairr NS, Leftwich TJ, Esquivel MF, Duong AK, Turner SA, Ferreira-Gonzalez A, Olex AL, Sartorius CA, Dozmorov MG, Harrell JC. Stratification of Tamoxifen Synergistic Combinations for the Treatment of ER+ Breast Cancer. Cancers (Basel). 2023 Jun 14;15(12):3179. doi: 10.3390/cancers15123179. PMID: 37370789; PMCID: PMC10296623.
MacGowan J, Cardenas M, Williams MK. Vangl2 deficient zebrafish exhibit hallmarks of neural tube closure defects. bioRxiv [Preprint]. 2023 Nov 9:2023.11.09.566412. doi: 10.1101/2023.11.09.566412. PMID: 37986956; PMCID: PMC10659374.
Perez R, Park Y, Hirano A, Brecha N, Frankfort B, Zuniga-Sanchez E. Modeling subcellular specificity in the developing retina. Res Sq [Preprint]. 2023 Aug 8: rs.3.rs-3214285. doi: 10.21203/rs.3.rs-3214285/v1. PMID: 37609217; PMCID: PMC10441513.
van der Heijden ME, Rey Hipolito AG, Kim LH, Kizek DJ, Perez RM, Lin T, Sillitoe RV. Glutamatergic cerebellar neurons differentially contribute to the acquisition of motor and social behaviors. Nat Commun. 2023 May 15;14(1):2771. doi: 10.1038/s41467-023-38475-9. PMID: 37188723; PMCID: PMC10185563.
Neves LL, Hair AB, Preidis GA. A systematic review of associations between gut microbiota composition and growth failure in preterm neonates. Gut Microbes. 2023 Jan-Dec;15(1):2190301. doi: 10.1080/19490976.2023.2190301. PMID: 36927287; PMCID: PMC10026866.
Qi X, Chen J, Jiang X, Lu D, Yu X, Lin H, Monroy EY, Wang MC, Wang J. Quantification of glutathione with high throughput live-cell imaging. bioRxiv [Preprint]. 2023 Jul 12:2023.07.11.548586. doi: 10.1101/2023.07.11.548586. PMID: 37503234; PMCID: PMC10369946.
Kircher BK, McCown MA, Scully DM, Behringer RR, Larina IV. Structural analysis of the female reptile reproductive system by micro-computed tomography and optical coherence tomography鈥. Biol Reprod. 2024 Apr 19: ioae039. doi: 10.1093/biolre/ioae039. Epub ahead of print. PMID: 38641547.
Schmid W, Danstrom IA, Crespo Echevarria M, Adkinson J, Mattar L, Banks GP, Sheth SA, Watrous AJ, Heilbronner SR, Bijanki KR, Alabastri A, Bartoli E. A biophysically constrained brain connectivity model based on stimulation-evoked potentials. J Neurosci Methods. 2024 May; 405:110106. doi: 10.1016/j.jneumeth.2024.110106. Epub 2024 Mar 5. PMID: 38453060.
Schmid W, Danstrom IA, Echevarria MC, Adkinson J, Mattar L, Banks GP, Sheth SA, Watrous AJ, Heilbronner SR, Bijanki KR, Alabastri A, Bartoli E. A biophysically constrained brain connectivity model based on stimulation-evoked potentials. bioRxiv [Preprint]. 2023 Nov 6:2023.11.03.565525. doi: 10.1101/2023.11.03.565525. Update in: J Neurosci Methods. 2024 Mar 5; 405:110106. PMID: 37986830; PMCID: PMC10659345.
Qiu L, Chirman D, Clark JR, Xing Y, Hernandez Santos H, Vaughan EE, Maresso AW. Vaccines against extraintestinal pathogenic Escherichia coli (ExPEC): progress and challenges. Gut Microbes. 2024 Jan-Dec;16(1):2359691. doi: 10.1080/19490976.2024.2359691. Epub 2024 Jun 2. PMID: 38825856; PMCID: PMC11152113.
Xing Y, Clark JR, Chang JD, Zulk JJ, Chirman DM, Piedra F-A, Vaughan EE, Hernandez Santos HJ, Patras KA, Maresso AW. Progress toward a vaccine for extraintestinal pathogenic E. coli (ExPEC) II: efficacy of a toxin- autotransporter dual antigen approach. Infect Immun. 2024 May 7;92(5): e0044023. doi: 10.1128/iai.00440-23. Epub 2024 Apr 9. PMID: 38591882; PMCID: PMC11075464
Sobhani N, Tardiel-Cyril DR, Chai D, Generali D, Li JR, Vazquez-Perez J, Lim JM, Morris R, Bullock ZN, Davtyan A, Cheng C, Decker WK, Li Y. Artificial intelligence-powered discovery of small molecules inhibiting CTLA-4 in cancer. BJC Rep. 2024;2:4. doi: 10.1038/s44276-023-00035-5. Epub 2024 Jan 23. PMID: 38312352; PMCID: PMC10838660.
Anaya ES, de Groot EL, Lydon JP, Pangas SA, Hartig SM. Contributions of white adipose tissue to energy requirements for female reproduction. Trends Endocrinol Metab. 2024 May 14: S1043-2760(24)00095-X. doi: 10.1016/j.tem.2024.04.012. Epub ahead of print. PMID: 38749883.
Felix JB, Saha PK, de Groot E, Tan L, Sharp R, Anaya ES, Li Y, Quang H, Saidi N, Abushamat L, Ballantyne CM, Amos CI, Lorenzi PL, Klein S, Gao X, Hartig SM. N-acetylaspartate from fat cells regulates postprandial body temperature. Res Sq [Preprint]. 2024 Jan 9: rs.3.rs-3835159. doi: 10.21203/rs.3.rs-3835159/v1. PMID: 38260478; PMCID: PMC10802732.
Padilla J, Osman NM, Bissig-Choisat B, Grimm SL, Qin X, Major AM, Yang L, Lopez-Terrada D, Coarfa C, Li F, Bissig KD, Moore DD, Fu L. Circadian dysfunction induces NAFLD-related human liver cancer in a mouse model. J Hepatol. 2024 Feb;80(2):282-292. doi: 10.1016/j.jhep.2023.10.018. Epub 2023 Oct 27. PMID: 37890720; PMCID: PMC10929560.
Anselmi C, Fuller GK, Stolfi A, Groves AK, Manni L. Sensory cells in tunicates: insights into mechanoreceptor evolution. Front Cell Dev Biol. 2024 Mar 14; 12:1359207. doi: 10.3389/fcell.2024.1359207. PMID: 38550380; PMCID: PMC10973136.
Halpert MM, Burns BA, Rosario SR, Withers HG, Trivedi AJ, Hofferek CJ, Gephart BD, Wang H, Vazquez-Perez J, Amanya SB, Hyslop ST, Yang J, Kemnade JO, Sandulache VC, Konduri V, Decker WK. Multifactoral immune modulation potentiates durable remission in multiple models of aggressive malignancy. FASEB J. 2024 May 31;38(10): e23644. doi: 10.1096/fj.202302675R. PMID: 38738472.
