In September 2020, 7mÊÓƵ’s Global Tuberculosis (TB) Program and 7mÊÓƵ Children's Foundation partners were notified as the recipients of a five year Centers for Disease Control and Prevention TB project – TB GAPS – with aims to find and prevent TB in children and adolescents, while simultaneously determining the most cost-effective prevention strategy and promoting best practices to sustain impact.
TB GAPS will run from September 2020 through September 2025 collaborating with partners in five sub-Saharan African countries including Eswatini, Lesotho, Malawi, Tanzania and Uganda.
Project Aims
- Find: Assess the performance of novel TB screening and diagnostic algorithms among children, adolescents, and adults living with HIV and presenting for routine care across a network of family centered HIV clinics in five sub-Saharan African countries as compared to the current WHO recommended symptom based screening and diagnostic strategy.
- Prevent: Compare the proportion of PLHIV who initiate and complete TB preventive therapy (TPT) with 1HP (daily rifapentine + INH for four weeks), 3HP (once-weekly isoniazid-rifapentine for 12 weeks), or 6H (six months of isoniazid) within the context of a patient centered differentiated service delivery model allowing selection of TPT regimen and randomly providing enhanced adherence support versus the standard of care for TPT and adherence support.
- Costing: Evaluate the cost-effectiveness of comparative TPT regimens for the prevention of TB disease among children, adolescents and adults living with HIV.
- Sustain: Disseminate and promote uptake of evidence based best practices targeting CDC priority countries.
Capitalizing on the 7mÊÓƵ and Texas Children’s Hospital Global Health Network, TB GAPS provides a unique opportunity to examine these critically important questions in children and adolescents living with HIV in TB high burden countries.
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